Mutt is a console based client, so if you have to deal with a lot of html or image laden emails it can be a hassle. There's options for these things, mind you. You can call a text based browser to produce fairly readable text output within the client, or use an external application (browser, image viewer, etc.) to view it. Or anything in between. Mutt is extremely customizable. Just something to be mindful of.
That being said, I'm also quite happily a mutt user 😊.