Before the paywall cuts it off, it does clarify the gain is just caloric restriction.
Cell division just slows down, and cell division is longevity. After so many division shit starts falling apart. So slow down how often cells divide, and you put off the effects of aging.
This has been common scientific knowledge for decades, and it would be weird if we didn't see it here.
The mice taking semaglutide during the study self-reduced their calorie intake by 24%. So, to check whether this was the cause of the observed effects, the authors put an extra, untreated group of mice on a diet that matched the calorie-intake level of the GLP-1-treated mice. The two groups showed similar longevity outcomes. However, the GLP-1-treated mice performed better than did those in the diet group in several experiments, including one testing spatial memory, in which animals had to remember the location of the exit to a maze. “That was really a surprise to us,” Chen says.
This result suggests that semaglutide has further benefits that are not explained by calorie reduction, she explains. But the driver of those benefits is still unclear.
Seems kind of obvious...
That caloric restriction makes your brain focus on getting calories.
Semi-glutides make your brain stop caring, so it naturally doesn't get distracted from caloric restriction. So no cognitive effects
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