LoglineA shuttle accident leads to Spock’s Vulcan DNA being removed by aliens, making him fully human and completely unprepared to face T’Pring’s family during an important ceremonial dinner.
ENT actually did this, which is odd to think how pioneering that series was at the time.
But there were several plot lines that built up over the series and some which didn't even have pay off until the last season just before the series was canned.