Yeah, in general, you'll be fine with Firefox and any of the default filters uBlock provides (even the ones that are disabled by default). The issue usually comes from outdated third-party filter lists that try to block youTube's tracking. Since the changes, you should pretty much only rely on the official lists for anything YouTube-related.

Or maybe OP's got another extension that tries to block ads. I know I've had to disable Enhancer for YouTube's ad blocking (because YouTube detects it immediately).