I can easily accept a blind npc or pc, and also a wheelchair npc, but a wheelchair pc is a bit convoluted in a fantasy setting. Like this was literally a subplot in doctor strange. There is just too much power in player parties to not knock this out in the first few adventures.

Whether through healing or artifacts or levitation. Just makes no sense unless you want the tactical “guy in a chair” trope, or want to have navigation be a major part of each story.