Absolutely. I rarely vote for the majority party candidate, and I'll often rotate between the minority (Dem in my case) and third parties/independents depending on the candidate.

I'm not in a swing state, so I have the benefit of always feeling like I can always vote my conscience instead of picking the lesser of two evils. However, that should ideally be the case everywhere, so we really need voting reform so you can always vote your conscience without worrying about "a vote for X is a vote for Y" nonsense.