I use endless incremental method with 60 days history. So I always have 60 days to go back with having only one full backup that gets the expired incrementals merged automatically. This way the daily backup only takes a few minutes and it doesn't need too much overhead space to store multiple full images as with other methods. It is also encrypted and uses VSS so it can backup everything on a live system. Sends email if there was a problem, supports pre an posts scrips to mount my backup drive, etc.

I also do independent full backups occasionally of course, but the previous one is the main reason for Macrium. Sometimes I just use it to dump other disks or old SDcards to a compressed image file that I can mount and use easily if needed.