As someone said you solution is to symlink or setup LVM volume groups for different mount points. Essentially, it's all or nothing. You can't just put a single program on a different disk without then taking all those files and manually symlinking them to the right place. It's honestly one of the biggest Linux oversights.

Symlink your desired location on the target disk to the place the system thinks the software should go. (In my case, /usr/local/games is a symlink to a different drive.)