That it is ultimately inconsequential is the reason for me to relax and enjoy what we have right now. Easier said than done, of course, but the way I think of it is this: if nothing I do matters, then it doesn't really matter what I do. And when I find myself taking things too seriously, it helps to be reminded of it. Life is absurd, but it doesn't matter, so why not have some silly fun in the meanwhile?
What the ultimate reality of things are doesn't really matter to us living in this reality. To whatever end this reality was created for, if, for example, we're just a simulation, we can't really know and at the end of the day, shouldn't really care about. It's literally (in both senses of the term) way beyond us.