I’ve been running mine for over 20 years. It’s certainly got more difficult, especially to be able to reliably communicate with Gmail-hosted servers and outlook.com addresses, but SPF, DMARC, and DKIM are all pretty straightforward to set up. Tightening the encryption/hash algorithms you accept and “anonymizing” your server greetings takes some finesse as well, but I definitely prefer it this way.
I avoid the entire webmail and spam filtering aspects, smtp(s) and imap(s) only.