Of course, it's a play on the Mean Girls meme "Get in loser, we're going shopping"

Pictured are two characters from the mid-nineties series Babylon 5, both of whom risked their lives and made personal sacrifices multiple times in order to defeat the primary antagonist, "The Shadows". Central in that fight is "The One", prophesied by the same species as the bald boneheaded person in the picture