Honestly given that we are a very intelligent generalist, I think it would be very hard to completely eradicate humans.

But I would agree that we could have a crazy bad collapse and have to start way over due to a much smaller habitable part of the planet and maybe that habitable area shifts around making us nomadic or something. That would probably make it a lot harder to redevelop tech. Source: https://www.open.edu/openlearn/nature-environment/environment-understanding-atmospheric-and-ocean-flows/content-section-4

Figure 18 shows that such a warm, stable period has been very unusual in the last 800 000 years, yet it is only during the Holocene that agriculture and the civilisations that rely on it have developed