I have been (for longer than a couple of months) in Tampa, New Orleans, LA, they are different but all speak American English Tampa & New Orleans feel older, and out West does feel different.
The highway system is federal and those interstate roads all do look the same.
And all of the medium sized cities do have some road (here in Tampa it's Dale Mabry) that you could pretty much plop down into any other medium sized city, switch them without anybody noticing. Miles of strip malls. Impossible to cross safely on foot.
