You can read it. It won't be Dune, but you can read it.

I did read the house prequels some time ago and they were not unreadable, but still a far cry away from real Dune.

Since you've apparently started reading the expanded universe sequels I should just say (trying to avoid spoilers as much as possible) their idea of what was the "final enemy" of Dune is not at all what was suggested in Frank Herbert's works, and apparently requires reading their Butlerian Jihad prequels (which likewise aren't anything like how the Jihad was portrayed by in the actual Dune series).