Depends if we can adapt them quickly enough to survive.

Brazil has been dismantling our biotech sector for 20 years now, so I'm not optimist, but YMMV.

Anyway, I'm more optimist on avoiding problem than on dealing with it.

High temperatures don't preclude large lifeforms. Just ask the dinosaurs.

But you need the ability to adapt at speed and scale for the entire ecological colony. You can't rely on biomes that cater exclusively to a handful of apex predators.