Most of the best Universities in the world.

Not sure if the world agrees. You certainly have a lot of universities in the country. Also not sure about best hospitals...

House prices are much more reasonable in the USA. Obviously it's a huge country and it depends where you want to live, but in comparison house prices in Canada make no sense whatsoever.

Culturally, very similar. There are subtle differences. Americans are louder and more confident in general I think. Also way more business oriented. People in general seem less healthy but the disparity with Canada isn't that big anymore. Wealth disparity is though. Way more very poor people, way more really rich people. In Canada I'm a top 1% earner. In the USA I'm not really even close.

The obvious major difference from Canada is health insurance. If it's not covered by your employer (92% of Americans have coverage last I checked), I hope you have some disposable income to pay to pay for health insurance. That being said, taxes are usually way lower depending on which state you're in, so you very well might come out ahead, even with copay and deductible. For reference, I had a global health insurance plan with Cigna. It had 1 mil USD coverage and max out of pocket per year for me was like 3 k USD. That was 205 USD/month. This didn't cover general doctors visits, or anything related to that. It was basically for visits to the emergency room. So if you're looking for coverage at the same level as Canada, you're going to be paying more. I have heard from numerous sources that the health care in the USA is way better than in Canada--as long as you can pay for it.

These are broad generalizations. USA is a very diverse place. Of all places I've been in the world, USA is the most similar to Canada, and Australia probably comes second.