My uninformed opinion: Too big, too expensive, mostly useful for arcade games (up to the Neo Geo) but I would not use them for anything else. Even for Super Nintendo, Megadrive, or other consoles, I don't think they would help. Also you need some space to put them on a desk or on your lap. Small gamepads don't have that limitation.
I currently have the cheap Nintendo Switch Pro controller thing, and it's perfect for most usage: Steam games, and every kind of retro emulation.