PU "leather" is good for a lot of things, depends a lot on quality though. There are various shoe companies that use it.
There are several more natural leathery materials for clothing but they're a bit more niche so they're expensive. Like cactus leather. I've never bought it because of the price.
I usually just try to use non-leather things. Waxed cordura or cotton performs well, looks cool, and is usually something I prefer anyways for its proprieties (with at least 20% cotton it breathes a bit when dry and seals when wet).
