She has entire adventures with Data, in the holodeck!
I guess maybe if you watched the show as it aired, yeah you could have some sympathetic animosity... but she's just like, busy, and has no time for bullshit, and Data sometimes does not realize he is doing a bullshit.
Like I'm autistic and highly identify with Data... people being a dick to you for seemingly no reason you can understand, this is extremely relatable and normal for an autist.
I'd argue the two of them, Data and Pulaski, in particular serve as a great model of how a neurotypical and autist can learn how to interact with each other; she indulges his special interest and they go on a Sherlock Holmes adventure together!
And in so doing, he learns about things she notices, knows, and values, that were not apparent to him before... and the same in reverse... they each respect each other more after that, and learn a bit how to avoid frustrating the other.