It's probably different for different people. I smoke a fat bowl every morning, and sometimes a second one at night, and I'm fine. I've been smoking for about 40 years. My wife was smoking a gram or two a day for roughly 18 months, and she developed CHS. She took a month long t-break, and the symptoms went away. Now, if she smokes more than once a week, they come back, so she only smokes with me on Monday nights.