I'm switching to GuixSD. Fortunately I have an old laptop and can build up my system there until I feel confident enough to do the real switch.
Pros I have encountered so far: booting in 20 seconds. Nice, although small, community. Scheme is cool. When the time comes, I will just need to copy two text files (and my dotfiles) to the main laptop, and my system will be (theoretically) the same, and it will be (theoretically) unfuckable.
Cons I have encountered so far: some kinks that were quick to research and fix while on an Arch-based distro, now are a bit more of a pain (but most of them in the fun way at least). For now I have given up trying to make the Thunar archive plugin work and switched to PCmanFM. Also I had to install Logseq as a flatpak. I have started very recently and I have not installed much yet so no idea about the impact on gaming.
ETA: there's !guix@lemmy.ml and !guix@infosec.pub on Lemmy.