The biggest difficulty is music production plugins. Some have a Linux version, some work via yabridge and wine (with some GUI bugs), and some don't work at all.
On top of that, my initial attempt was using Mint with all of the audio optimisations (including kernel) but it was stuttery and slow. Unfortunately, oving to another distro is not painless when you have to move all the plugins too but CachyOS has been much better so far.