Red Dead Redemption 2
I am an emotional person, and I regularly cry during movies, shows and books. But this is the first and only game to day, where I cried. I don't mean just teary-eyed, actually crying. And on more than one occasion.
It made me want to be a better person. Hopefully I am succeeding.
Cyberpunk 2077 is close second.
I didn't play Expedition 33 yet, but I saw the prologue and it was very emotional. There is a really good chance this game will be on my list too.