Not for most games. Usually modding is just putting the files in the right folder, so it isn't a big deal and you don't need a manager, but it is good when you have 100+ mods.

Again though, Vortex is usable with WINE, just not ideal. For anyone curious, you need to install it into the prefix with the game and, IIRC, create a virtual link to the mod directory, or something like that. It's been a while since I've done it. It's not that difficult but, from my experience, you should expect to have a warning or two that you just have to ignore.

This is the new app that will be replacing Vortex, and it works on all platforms natively. It only officially supports a handful of games though, like Stardew Valley and Cyberpunk, for now.