It really depends on the game. For things that are fundamentally PvP with a bunch of players, sure. 1v1 games sometimes use a bunch of other solutions and if there are big PvE components things may get complicated.
And that's why I said "maybe" up there and why I went with cloud gaming as the default. Rendering on client means you can still do all sorts of crap in terms of wallhacks, spoofing inputs and so on. I really wonder how safe even cloud gaming would be. Could you do effective autoaim with just a rendered frame fast enough? I bet somebody would try.
Hell, in some cases the cheating isn't even on software these days. CS had a big argument about some keyboard behaviors recently, as did fighting games about leverless sticks enabling certain shortcuts. I genuinely don't know the current state of affairs around those these days.