Man found missing 90% of his brain defies scientific understanding - most of his skull is filled with water:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)61127-1/fulltext
My advisor liked to joke that I was cursed.
It didn't have quite the same level of personal impact, but I used to associate with a geologist who said something similar about me and geodes.