I really enjoy using FATE for plenty of different genres. I played in a magic/cyberpunk/not shadowrun game, and the stunts worked really well for the magic spells second character had, and an aspect for the brain implant that allowed my first character to see magical energies. And a fantasy game I ran once it worked really well in letting my players explore character types without the strict adherance to class in D&D. And I'm using it currently for a Space Pirate game.