I personally don't trust NodeJS libraries that much - I always run projects inside Docker as a regular user with access to the working directory, just in case the supply chain is poisoned.
In the case of Python, particularly when I was testing out the LLaMA model, I just stood up a new VM for that. Back then safetensors wasn't a thing, and the model tensor file format (python pickle-based) could potentially store arbitary code.
Robust standard libraries are amazing to have.