Not even factoring in killing any sort of mod support (prob not the biggest concern for Payday, but in a general sense it matters) Denuvo is notorious for hurting performance, but the makers aren’t really incentivized to optimize anything because gamers aren’t their customers. The publishers pay the cost to use it. The gamers just feel the cost. Especially if the game is a PC port that already has optimization issues.
Almost all games that are protected by Denuvo anti-tamper suffer from increased loading times, lower frame rates, and other performance issues.