In my last game, the Ilhome cluster event with those fanatic purifiers happened, and I was playing some militarist, communist space cacti. I had refugees welcome as the fanatical purifiers captured a quarter of the galaxy. Then I declared war on them and quickly overwhelmed them, since they had overextended. During the 10 years of peace after the war, I was constantly busy ordering new districts and buildings build, so much that I regularly ran out of minerals, despite buying 1000 minerals each month.

So basically, late game there's too much paperwork for the turbo setting.