You look at their voting record and public statements, and vote for the one that is most likely to support legislation and policies that align with your values. That's what I mean by "voting for."
So if it's essentially a certainty that they won't, what do you do in the general?
ETA: Besides Manchin and Sinema, who are going independent anyway, which examples of Dems are Republicans with a D in front of their name?
Are you forgetting about uncle Joe?