Google's anti-ad scripts are breaking browsers and privacy plugins. It could get worse because Google controls the ad market, Chrome, and the extension store.
I never had to touch anything in uBlock Origin, not even once, I just have to remember to check for updates every now and then. I see some people saying sometimes they still get ads on youtube, not sure if it's youtube testing new targeting, but I've never seen ads on YT anyway, I guess I'm not interesting enough to them XD