How safe a car trip is, can be influenced a lot by the driver.
The same could be said of issues with flights. The difference is you're not the driver, but also there are many, many more layers of safety in flying.
Only one thing has to go wrong for a car crash, which could easily be completely out of control of the driver and their vehicle (eg another driver). Several things have to go wrong for a plane to crash, the holes in many layers of Swiss cheese have to align.