If I understand the nature of your hardware correctly, you should be able to run the MoE models like Gemma4 26B-A4B or Qwen3.6 35B-A3B at a high quantization fairly performantly.

You could try running some of the dense models (like today's Qwen 3.8 27B) as well, but I expect they'll be pretty slow (judging by my own experience with a unified RAM system that has a Strix Halo APU). Might still be useful for tasks that you can leave running on their own for a long time instead of for interactive chat style interaction though.

You've got enough RAM to load larger models, but there hasn't been much released in between the "it fits on a 24GB or 32GB GPU that a gamer might own" and the "oh god you need HOW MUCH RAM!?" scales lately...

With Q4 everything below 150B should be fine. You can also run the -Flash variant of this model in Q1, but it is probably not usable.