I'm thinking of yearly trips. My in-laws live far enough away that it is a major trip to visit. Flying the family is expensive so often we make it a two or three day road trip. We try to see something weird everyday so it won't be the same roads or stops. The general plan is head southwest until we hit i10, about 3 pm we book a hotel that we will arrive at around 6, and use GPS to ensure we do, but otherwise there is no reason for using any particular road.