It's my understanding that the Oxford comma only exists in lists that are at least three items long. So in the case of the original comic, there can not be an Oxford comma.

One element of the humor in this comic is the ambiguous place the comma occupies for representing a pause in English speech.

Unfortunately, my favorite punctuation for this type of pause in written English---the em dash---is now a sign of AI writing.

Consider,

• "Girls, X or Y?"
• "Girls---X, or Y?"

Both convey the nuances of pauses and emphasis in spoken English slightly differently.