I think it depends on your source.
If we are talking about a downloaded good high bit rate MP3 and a FLAC, then yeah, I can't hear a difference.
For streaming, I CAN hear a difference between the default spotify stream and my locally stored lossless files. That difference might come down to how they are mastered or whatever spotify does to the files, but whatever it is the difference is pretty perceptible to me and I don't have especially sensitive ears.