Try using a folder symlink that encompasses the game's folder, so that the game thinks it is on the main drive, but is actually on the secondary drive. Might work around whatever issue is here.
Steps:
-
Create a folder for the game: /home/Games/SpecificGameWithAnIssue
-
Create a symlink from /home/Games/SpecificGameWithAnIssue to /mnt/DriveTwo/WhereTheGameNowLives
-
Install game to /home/Games/SpecificGameWithAnIssue
-
Run game