I work in an industry where we use computers all day and this is painfully clear. I grew up with a mouse in my hand, shortcuts are hardwired into my brain. Watching someone right click them slowly move the cursor to copy, then right click and slowly move to paste, then slowly navigate to formulas then click refresh is brutal. It literally takes them 3-4x as long as it takes me to do the same task.
On the bright side, I only work about 20 hours a week and still outperform them, so thanks I guess?