At this point, any programs that won't work in Wine either have a component that cannot be run in Linux (kernel level anti-cheat for example) or has a DRM/execution stack that enforces Windows use (ie Abobe.) Most of my Windows emulation is gaming, and I've managed to get Fitgirl installers and even cracks/updates to run through Wine and Proton. My opinion only: At this point any program that won't run on Linux is intentional, either by design, or by neglect.