It really depends a lot on what programs you are running, what exact version of Wine/Proton/... you are running and how it's configured.

Wine is finnicky, but it can totally also just be bad luck, depending on what you try to run. Wine on x86 works quite well for me. x64 has issues more frequently, and combining it with Box86 to run it on ARM is more miss than hit.

Also, Wine is advancing pretty fast, so stuff that didn't work a while ago might work now.