Maybe yes. Maybe not. I think from now they won't push that far, among other things because even developing for android platform would become a burden. Not being able to even test some app concept without a verified signature...
Maybe eventually they'll go that far. But as of now I do think is unlikely they'll completely block the adb way.
Anyway many current users won't go adb. And third party stores will take a massive hit. That's google's goal.