I've been using a Corne-ish Zen at work for a couple years now. It's a split 3x6 grid (columnar staggered) with three thumb keys on each half.

Numbers are home row with a left thumb modifier, symbols are home row with a right thumb modifier. F-keys the row above with the same modifiers. Navigations is yet another modifier (holding down semicolon actually), with IJKL for arrows, H for home, N for end.

Everything is either zero or one keys away and zero or one layers away.

I have a Kyria too, as another poster mentioned. But I wanted to try low profile choc switches and prefer them for work. BLE is pretty nice too.