I definitely wouldn't mind soldered RAM if there's still an expansion socket. Solder in at least a reasonable minimum (16G?) and not the cheap stuff but memory that can actually use the signal integrity advantage, I may want more RAM but it's fine if it's a bit slower. You can leave out the DIMM slot but then have at least one PCIe x16 expansion slot. A free one, one in addition to the GPU slot. PCIe latency isn't stellar but on the upside, expansion boards would come with their own memory controllers, and push come to shove you can configure the faster RAM as cache / the expansion RAM as swap.
Heck, throw the memory into the CPU package. It's not like there's ever a situation where you don't need RAM.