I think the biggest limiting factor for your mini PC will always be the VRAM and any workload that enjoys that fast RAM speed. Really, I think this mini PC from framework is only sensible for certain workloads. It was poised as a mobile chip and certainly is majorly power efficient. On the other hand I don't think it is for large scaling but more for testing at home or working at home on the cheap. It isn't something I expected from framework though as I expected them to maintain modularity and the only modularity here is the little USB cards and the 3D printed front panel designs lol

Edit
Personally I am in that niche market of high RAM speed. Also, access to high VRAM for occasional LLM testing. Though it is an AMD and I don't know if am comfortable switching from Nvidia for that workload just yet. Renting a GPU is just barely cheap enough.