That's a different threat vector, but was also eliminated in other games. RuneScape devs, let's face it, are really stupid.

For auto clickers, and the like, just make sure whatever is happening is possible for a human to do, auto clickers are faster than humans so they're easy to catch. If they're using it to move, that's a predictable thing that can be fixed by changing the terrain slightly like wow did to catch and ban a few million bots at a time.

Kernel anti cheat would not be effective against that vector anyway, as memory isn't changed in most cases.