this post was submitted on 23 Jul 2023
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It'd be best to try a few sets for yourself and feel the difference.
Personally I don't care about tone and I'm not of the opinion that you get much better tone with heavier strings (as some people claim) but string gauge is important if you do serious down tuning (I mean more than half a step) because the strings will get floppy and that'll make playing a bit more weird/difficult if the string is flopping all over the place.
If you're not tuning lower than standard E maybe try a lighter set next time (than the 10-46 you mentioned) and see how that feels. It should feel much easier to fret the notes and do bends.