The much maligned "Trusted Computing" idea requires that the party you are supposed to trust deserves to be trusted, and Google is DEFINITELY NOT worthy of being trusted, this is a naked power grab to destroy the open web for Google's ad profits no matter the consequences, this would put heavy surveillance in Google's hands, this would eliminate ad-blocking, this would break any and all accessibility features, this would obliterate any competing platform, this is very much opposed to what the web is.
As a full stack guy that has done his fair share of front end work, I use an adblocker on the devices that I use in my personal realm. I don't have them in my development area because most people don't use them. I want what I test on to be as stock as possible. I've observed that most people go with what "comes out of the box." That said, I get to look at my efforts on my personal devices. If something is off, I'll see it. If I had to code to every popular extension, it would be hard to get anything done.