idea: let each instance have a prepopulated blocklist
let the admins of each instance have a list of blocked users that gets inherited to members of that instance, but let users remove from that list as well as add to avoid abuse. and don't hide the comments from these users, just collapse them to let people know a comment has been hidden in case of mistakes
(possibly even allow regex to avoid RandomWord1234
, which was common on reddit)
this is a rather extreme tactic though, only for if spam becomes overwhelming