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this post was submitted on 16 Apr 2025
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Fun fact! That pill is not commonly prescribed anymore (I hope it isn't prescribed anywhere at all really) as it is horse estrogen derived from the urine of pregnant horses! It used to be common back in the day, but these days we enjoy human estrogens instead with no extra side effects.
Ouch, so umm you mean there were side effects to... pregnant horse piss estrogen?
Yep. You risk a higher chance of getting blood clots on premarin. There may have been some other risks as well, but I don't remember those at the top of my head.
Trans women thought it gave them cone boobs, that was the gossip back in the trans group back in the day.
Lara Croft is a trans woman, cmv.
I think that tracks, the horse estrogen would have been good enough for estrogenic effects but bioidentical estrogen does better to trigger effects along the whole endocrine line. I know when my estrogen is in good levels it effects my progesterone cycle (in a good way) and progesterone in turn is commonly used to help round out breasts after tanner 4/5
I've never heard of taking estradiol resulting in more prog
Estradiol (bioidentical) does this as well, it's not a limitation of just premarin. I have two cones so I would know! You need progesterone generally to get rounder boobs (it promotes the growth of the milk ducts, E just promotes growth of the breast tissue itself).
Now also, as a disclaimer, what I just said about cones and prog is partially anecdotal; prog hasn't been studied all that much yet, but quite a few transfems report cone boobs until they start prog (I will be starting it within a few months <3).
TIL, thank you.
To be fair, it's not human oestrogens collected from pregnant women or something, it's synthetic made in a lab. There's no difference in the estradiol (E2) molecule between different mammals, so the stuff we use now could be used for HRT for a horse. That's why the horse piss tiddy juice worked in the first place!
This appears not to be entirely correct: https://en.wikipedia.org/wiki/Conjugated_estrogens
I think you may have misunderstood my comment. I was speaking to this part of yours:
In that what we use now isn't really "human" oestrogen, because it's synthetic, and oestrodiol is pretty much universal among mammalian species.
True. I said human estrogen because the ones found in premarin aren't found in humans, while the new bioidentical ones are.